Biological Effects of Pollutants

Code:

152506

ECTS:

4.0

Lecturers in charge:

izv. prof. dr. sc. Petra Burić

Lecturers:

izv. prof. dr. sc. Petra Burić - Seminar

Take exam:

Studomat

1. KOMPONENTA

• Lectures 30
• Seminar 15

* Load is given in academic hour (1 academic hour = 45 minutes)

DESCRIPTION:

The course "Biological Effects of Xenobiotics" is focused towards defining the concept of xenobiotics and their biological effects. The terms bioavailability, bioconcentration, bioaccumulation, biomagnification and biotransformation of pollutants are explained in detail and precisely defined. The molecular pathways and mechanisms of xenobiotics entry, metabolism and removal from living systems are described. An overview of the most important groups of pollutants, their physical and chemical properties and biological activity is given. The sub-lethal effects of xenobiotics on the macromolecular level, cell organelles/structures and cells/tissues are considered in detail. The mechanisms of toxic and genotoxic effect of contaminants are described and results of the latest scientific research in marine organisms (invertebrates, fish) are discussed. During the lectures - thematic units, the effects of physical ( - and UV rays, free radicals) and chemical contaminants (PAHs, PCBs, pesticides, heavy metals, estrogen, artificially synthesized nanoparticles and structures ...) on DNA (different types of damage), the induction of mixed function oxidase (CYP) and phase I and II enzymes, the multi-xenobiotic resistance (MXR) mechanism, the induction of metallothioneines, oxidative stress, immune response, apoptosis, heat shock proteins (HSP), the modulation of the endocrine system (induction of vitellogenin), inhibition of acetylcholinesterase activity, and effect of manufactured nanomaterilas as indicators of exposure and biological effects of pollutants at the molecular and cellular level are studied.

LITERATURE:

1. Željko Jakšić; radni materijali dostupni dostupni korištenjem Sustava za učenje na daljinu i online potporu nastavi;
2. znanstveni radovi (u dogovoru s nositeljem kolegija);
3. Michael J. Derelanko, Carol S. Auletta; Handbook of Toxicology, Third Edition; CRC Press (2014), str. (object Object)
4. Francois Gagne; Biochemical Ecotoxicology; Elsevier (2014), str. (object Object)
5. Mikko Nikinmaa; An Introduction to Aquatic Toxicology; Academic Press (2014)
6. Doris Abele, Jose Pablo Vazquez-Medina, Tania Zenteno-Savin; Oxidative Stress in Aquatic Ecosystems; John Wiley + Sons (2011), str. (object Object)
7. Ramesh C. Gupta; Handbook of Toxicology of Chemical Warfare Agents; Academic Press (2015), str. (object Object)
8. John Timbrell; Principles of Biochemical Toxicology, Fourth Edition; CRC Press (2008), str. (object Object)
9. Nick Plant; Molecular Toxicology; Garland Science (2003), str. (object Object)
10. David J. Hoffman, Barnett A. Rattner, G. Allen Burton, Jr., John Cairns, Jr.; Handbook of Ecotoxicology, Second Edotion; CRC Press (2002)
11. S. J. Cutler, J. H. Block; Wilson and Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry. Ch. 3, Metabolic Changes of Drugs and Releated Organic Compound; Lippincott Williams + Wilkins (2011)
12. Doris Abele, Jose Pablo Vazquez-Medina, Tania Zenteno-Savin; Oxidative Stress in Aquatic Ecosystems; John Wiley + Sons (2011), str. (object Object)
13. Urs A. Boelsterli; Mechanistic Toxicology; CRC Press (2007), str. (object Object)
14. Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood; DNA Repair and Mutagenesis; American Society for Microbiology Press (2005), str. (object Object)

6. SEMESTER

Mandatory course - Regular studij - Marine Science